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Dorsomorphin dihydrochloride
CAS No. 1219168-18-9
Dorsomorphin dihydrochloride ( BML-275 dihydrochloride;Compound C dihydrochloride )
Catalog No. M10824 CAS No. 1219168-18-9
Dorsomorphin (BML-275, Compound C) is a potent, selective and reversible AMPK inhibitor with Ki of 109 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 42 | In Stock |
|
| 10MG | 58 | In Stock |
|
| 25MG | 123 | In Stock |
|
| 50MG | 222 | In Stock |
|
| 100MG | 402 | In Stock |
|
| 500MG | 888 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameDorsomorphin dihydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionDorsomorphin (BML-275, Compound C) is a potent, selective and reversible AMPK inhibitor with Ki of 109 nM.
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DescriptionDorsomorphin (BML-275, Compound C) is a potent, selective and reversible AMPK inhibitor with Ki of 109 nM, shows no no significant activity on ZAPK, SYK, PKCθ, PKA and JAK3; inhibits AMPK activation induced by AICAR and Metformin, also inhibits bone morphogenetic protein (BMP) type I receptors (ALK2, ALK3 and ALK6); promotes cardiomyogenesis in mouse embryonic stem cells (ESCs) in vitro, induces autophagy in cancer cell lines via a mechanism independent of AMPK inhibition.
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SynonymsBML-275 dihydrochloride;Compound C dihydrochloride
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PathwayMembrane Transporter/Ion Channel
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TargetAMPK
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RecptorAMPK
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1219168-18-9
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Formula Weight472.40
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Molecular FormulaC24H27Cl2N5O
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Purity>98% (HPLC)
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SolubilityH2O: ≥ 48 mg/mL; DMSO: 5.2 mg/mL (Need ultrasonic)
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SMILESCl.Cl.C(CN1CCCCC1)OC1=CC=C(C=C1)C1=CN2N=CC(=C2N=C1)C1=CC=NC=C1
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Chemical NamePyrazolo[1,5-a]pyrimidine, 6-[4-[2-(1-piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)-, hydrochloride (1:2)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Yu PB, et al. Nat Chem Biol. 2008 Jan;4(1):33-41.
2. Vucicevic L, et al. Autophagy. 2011 Jan;7(1):40-50.
3. Diekmann U, et al. Stem Cells Dev. 2015 Jan 15;24(2):190-204.
4. Zhou G, et al. J Clin Invest. 2001 Oct;108(8):1167-74.
2. Vucicevic L, et al. Autophagy. 2011 Jan;7(1):40-50.
3. Diekmann U, et al. Stem Cells Dev. 2015 Jan 15;24(2):190-204.
4. Zhou G, et al. J Clin Invest. 2001 Oct;108(8):1167-74.
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